{"created":"2023-06-20T13:45:23.848188+00:00","id":143,"links":{},"metadata":{"_buckets":{"deposit":"ad3eff10-cbbc-4c99-8dec-c47abdf8560a"},"_deposit":{"created_by":12,"id":"143","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"143"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000143","sets":["71"]},"author_link":["167"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2010","subitem_date_issued_type":"Issued"}]},"item_10007_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"70389542","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究概要：HIVのプロテアーゼ阻害剤(PI)の一つであるアンプレナビル(APV)耐性HIV変異体で6個のGag変異を同定した。このGag変異を導入した感染性HIVクローンは、野生型HIVよりも早期にAPV耐性を獲得したが、別のPIであるネルフィナビル(NFV)に対しては遅延した。これはPIの曝露によって起こるGag変異がHIVのPIに対する耐性獲得に影響することを示唆しており、Gag変異の解析は薬剤の選択等、治療において有用であると思われた。","subitem_description_type":"Abstract"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"21790527","subitem_description_type":"Other"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-07"}],"displaytype":"detail","filename":"kaken.nii.ac.jp_21790527seika.pdf","filesize":[{"value":"227.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kaken.nii.ac.jp_21790527seika","url":"https://khsu.repo.nii.ac.jp/record/143/files/kaken.nii.ac.jp_21790527seika.pdf"},"version_id":"79b815f3-91e7-444b-88ee-84eb01faf605"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HIV","subitem_subject_scheme":"Other"},{"subitem_subject":"薬剤耐性","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテアーゼ阻害剤","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"青木, 学"}],"nameIdentifiers":[{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"HIVの高度薬剤耐性付与遺伝子変異の解析と耐性発現の克服","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HIVの高度薬剤耐性付与遺伝子変異の解析と耐性発現の克服"},{"subitem_title":"Role of HIV Gag mutations in acquisition of resistance to protease inhibitors.","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"12","path":["71"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-07-27"},"publish_date":"2015-07-27","publish_status":"0","recid":"143","relation_version_is_last":true,"title":["HIVの高度薬剤耐性付与遺伝子変異の解析と耐性発現の克服"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-06-20T13:49:27.827969+00:00"}