{"created":"2023-06-20T13:45:24.010286+00:00","id":146,"links":{},"metadata":{"_buckets":{"deposit":"c2761f65-7210-4998-946c-ec5fd81a294e"},"_deposit":{"created_by":12,"id":"146","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"146"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000146","sets":["71"]},"author_link":["38"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2013","subitem_date_issued_type":"Issued"}]},"item_10007_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"80389543","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究概要：Pr55Gagはホスファチジルイノシトール4,5-2リン酸｛PI(4,5)P2｝を介して宿主の細胞膜に結合することによりHIV-1ウイルス粒子を形成する。研究代表者らは、PI(4,5)P2よりも高度にリン酸化された人工PI(2,3,4,5,6) 5リン酸アナログを種々合成し、それらとPr55Gagの細胞膜結合部位であるMA蛋白質との結合活性を評価した。その結果、MA蛋白質に対して、同等の炭素鎖をもつPI(4,5)P2よりも約70倍強く結合するDi-C7-PI(2,3,4,5,6)P5 (化合物2)を見出した。本研究はPr55Gagの膜移行を阻害する化合物創製の基礎になりうると考えられる。","subitem_description_type":"Abstract"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"24790124","subitem_description_type":"Other"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-07"}],"displaytype":"detail","filename":"kaken.nii.ac.jp_24790124seika.pdf","filesize":[{"value":"343.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kaken.nii.ac.jp_19592620seika","url":"https://khsu.repo.nii.ac.jp/record/146/files/kaken.nii.ac.jp_24790124seika.pdf"},"version_id":"5a4d8f25-3f86-4c95-b545-4b62dd5c6404"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"抗エイズ薬","subitem_subject_scheme":"Other"},{"subitem_subject":"Pr55Gag","subitem_subject_scheme":"Other"},{"subitem_subject":"PI(4,5)P2","subitem_subject_scheme":"Other"},{"subitem_subject":"HIV-1","subitem_subject_scheme":"Other"},{"subitem_subject":"リン脂質","subitem_subject_scheme":"Other"},{"subitem_subject":"ジアシルグリセロール","subitem_subject_scheme":"Other"},{"subitem_subject":"イノシトールリン酸","subitem_subject_scheme":"Other"},{"subitem_subject":"BIACORE","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"安楽, 健作","creatorNameLang":"ja"},{"creatorName":"アンラク, ケンサク","creatorNameLang":"ja-Kana"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Ｐｒ５５Ｇａｇの膜移行を阻害する抗エイズ薬","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ｐｒ５５Ｇａｇの膜移行を阻害する抗エイズ薬"},{"subitem_title":"Design and synthesis of anti-HIV agents that inhibit the Pr55Gag membrane localization","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"12","path":["71"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-07-27"},"publish_date":"2015-07-27","publish_status":"0","recid":"146","relation_version_is_last":true,"title":["Ｐｒ５５Ｇａｇの膜移行を阻害する抗エイズ薬"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-04-11T08:35:02.650678+00:00"}