{"created":"2023-06-20T13:45:24.103289+00:00","id":148,"links":{},"metadata":{"_buckets":{"deposit":"f45ddaae-521f-4817-a910-4f75d898e116"},"_deposit":{"created_by":12,"id":"148","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"148"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000148","sets":["71"]},"author_link":["13","38","241"],"control_number":"148","item_10007_contributor_5":{"attribute_name":"研究分担者","attribute_value_mlt":[{"contributorAffiliations":[{"contributorAffiliationNameIdentifiers":[{}],"contributorAffiliationNames":[{}]}],"contributorNames":[{"contributorName":"松嶋, 和美","lang":"ja"},{"contributorName":"マツシマ, カズミ","lang":"ja-Kana"}],"familyNames":[{"familyName":"松嶋","familyNameLang":"ja"},{"familyName":"マツシマ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"和美","givenNameLang":"ja"},{"givenName":"カズミ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"13","nameIdentifierScheme":"WEKO"}]},{"contributorAffiliations":[{"contributorAffiliationNameIdentifiers":[{}],"contributorAffiliationNames":[{}]}],"contributorNames":[{"contributorName":"安楽, 健作","lang":"ja"},{"contributorName":"アンラク, ケンサク","lang":"ja-Kana"}],"familyNames":[{"familyName":"安楽","familyNameLang":"ja"},{"familyName":"アンラク","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"健作","givenNameLang":"ja"},{"givenName":"ケンサク","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"38","nameIdentifierScheme":"WEKO"}]},{"contributorNames":[{"contributorName":"安東, 由喜雄","lang":"ja"},{"contributorName":"アンドウ, ユキオ","lang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"241","nameIdentifierScheme":"WEKO"}]}]},"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2011","subitem_date_issued_type":"Issued"}]},"item_10007_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"70435163","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究概要：コレステリルエステル転送蛋白(CETP)阻害剤は、アポリポ蛋白(アポ) Eを多く含み粒子サイズの大きいアポE-rich HDLを上昇させることが知られているが、本HDLの測定法やコレステロール引き抜き能などの抗動脈硬化能については報告されていない。本研究で、我々は、CETP阻害剤と同様にアポE-rich HDLが上昇するCETP欠損や胆汁うっ滞患者血清を用いて、本HDLの抗動脈硬化能を明らかにし、さらに、アポE-rich HDLに反応特異性の高いポリアルキレングリコール誘導体の界面活性剤を用いて、アポE-rich HDLを含む総HDLのコレステロール測定法を開発した。","subitem_description_type":"Abstract"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"21590644","subitem_description_type":"Other"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-07"}],"displaytype":"detail","filename":"kaken.nii.ac.jp_21590644seika.pdf","filesize":[{"value":"338.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kaken.nii.ac.jp_21590644seika","url":"https://khsu.repo.nii.ac.jp/record/148/files/kaken.nii.ac.jp_21590644seika.pdf"},"version_id":"8281309c-564c-4b09-b6fb-05b9c3773970"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脂質","subitem_subject_scheme":"Other"},{"subitem_subject":"HDL","subitem_subject_scheme":"Other"},{"subitem_subject":"アポリポ蛋白E","subitem_subject_scheme":"Other"},{"subitem_subject":"アポE-rich HDL","subitem_subject_scheme":"Other"},{"subitem_subject":"コレステロール","subitem_subject_scheme":"Other"},{"subitem_subject":"アポ蛋白E","subitem_subject_scheme":"Other"},{"subitem_subject":"アポタンパクE","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"杉内, 博幸","creatorNameLang":"ja"}],"familyNames":[{}],"givenNames":[{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アポE-rich HDL-C測定法の開発と臨床応用に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アポE-rich HDL-C測定法の開発と臨床応用に関する研究","subitem_title_language":"ja"},{"subitem_title":"Development and clinical applications of a method for measuring apoE-rich HDL-C","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"12","path":["71"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-07-27"},"publish_date":"2015-07-27","publish_status":"0","recid":"148","relation_version_is_last":true,"title":["アポE-rich HDL-C測定法の開発と臨床応用に関する研究"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-04-15T02:53:00.584100+00:00"}