{"created":"2023-06-20T13:45:26.109636+00:00","id":193,"links":{},"metadata":{"_buckets":{"deposit":"d23e0462-dbb0-41d1-be52-1c545f800577"},"_deposit":{"created_by":12,"id":"193","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"193"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000193","sets":["22:81:84"]},"author_link":["325","295","300","299","297"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"15","bibliographicPageEnd":"61","bibliographicPageStart":"53","bibliographic_titles":[{"bibliographic_title":"熊本保健科学大学研究誌"},{"bibliographic_title":"Journal of Kumamoto Health Science University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A 型ボツリヌス毒素は神経終末部から込まれ，細胞質内に存在するSNARE 蛋白質のSNAP-\n25を特異的に切断し，破壊することが報告されている。その結果，運動神経終末部からは神経\n伝達物質であるアセチルコリン（ACh）の放出が阻害され，骨格筋への化学伝達が遮断，筋収\n縮が抑制されると報告されている。しかし，A2型ボツリヌス毒素（A2NTX）がin vivo 状態で\nどのように骨格筋の活動に影響を与えるかはほとんど報告がない。従って，本研究ではA2NTX\nが骨格筋収縮に及ぼす影響を，A2NTX 筋注ラットを用いて，トレッドミルランニング法とヒラ\nメ筋張力測定法でA1型ボツリヌス毒素（A1LL（BOTOX））筋注ラットと比較検討した。その\n結果，A2NTX は濃度・時間依存的にトレッドミルランニング走行時間を短縮させた。ヒラメ筋\n張力測定では筋の直接刺激においてはA2NTX とA1LL による筋張力抑制効果は全く認められ\nず，両毒素は筋自体には直接作用しないことが明らかになった。しかし，間接神経刺激では，\nA2NTX は１～20 U の濃度で完全に筋注側のヒラメ筋張力を抑制し，0.03 U では部分的な筋張\n力の抑制効果が発生した。また，反対側のヒラメ筋に対してもA2NTX は１～20 U で濃度依存\n的な筋張力抑制効果を発現した。これらの結果から，A2NTX は逆行性神経軸索輸送又は, 血液\nを介して反対側筋に影響を与えた可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本保健科学大学"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"24335002","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂本, 勝哉"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"田中, 哲子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"行平, 崇"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土井, 篤"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"申, 敏哲","creatorNameLang":"ja"},{"creatorName":"Shin , MinChul","creatorNameLang":"en"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-06-06"}],"displaytype":"detail","filename":"06-sakamoto-p053-061.pdf","filesize":[{"value":"3.9 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"06-sakamoto-p053-061","url":"https://khsu.repo.nii.ac.jp/record/193/files/06-sakamoto-p053-061.pdf"},"version_id":"0560145c-d2e3-4f02-8bfa-fae236be3bda"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"A2NTX","subitem_subject_scheme":"Other"},{"subitem_subject":"A 型のボツリヌス毒素","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒラメ筋","subitem_subject_scheme":"Other"},{"subitem_subject":"A2NTX","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"A1LL","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"botulinum neurotoxin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"soleus muscle","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"骨格筋収縮へのA2型ボツリヌス毒素（A2NTX）の抑制効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨格筋収縮へのA2型ボツリヌス毒素（A2NTX）の抑制効果"},{"subitem_title":"Effects of A2 type botulinum toxin（ A2NTX） on rat skeletal muscle","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"12","path":["84"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-06-07"},"publish_date":"2018-06-07","publish_status":"0","recid":"193","relation_version_is_last":true,"title":["骨格筋収縮へのA2型ボツリヌス毒素（A2NTX）の抑制効果"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-04-11T08:10:43.607984+00:00"}