{"created":"2023-06-20T13:45:27.255232+00:00","id":214,"links":{},"metadata":{"_buckets":{"deposit":"cf9c6490-8c4a-44cd-8d96-691c792be407"},"_deposit":{"created_by":12,"id":"214","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"214"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000214","sets":["22:81:87"]},"author_link":["332","334","187"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"16","bibliographicPageEnd":"140","bibliographicPageStart":"131","bibliographic_titles":[{"bibliographic_title":"熊本保健科学大学研究誌"},{"bibliographic_title":"Journal of Kumamoto Health Science University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"交差混合試験(cross mixing test;CMT)は活性化部分トロンボプラスチン時間(activated partial thromboplastin time；APTT)が延長した際に凝固因子欠損や凝固因子インヒビター，またはループスアンチコアグラントなどのインヒビターを鑑別するスクリーニングとして有用な検査である。しかしながら，学内実習では凝固因子インヒビターの検体入手が困難であることから実習では行っておらず，学生の理解が低いことが問題となっている。本研究では，dabigatran，apixaban，rivaroxaban がCMT における凝固因子インヒビター疑似検体として使用可能か否か検討した。APTT は凝固因子インヒビター疑似検体と正常血漿を様々な比率で混合し，コアプレスタ®2000を使用し測定した。Dabigatran は高濃度においてもAPTT の延長は認められなかったが，少量のrivaroxaban の添加(10%)においてAPTT 延長が見られ，凝固因子インヒビターパターンのグラフを示していた。APTT の延長はapixaban の添加でも認められた。一方，rivaroxaban はRosner index(index of circulation anticoagulant；ICA)による評価においても典型的なインヒビターパターンを呈した。さらにrivaroxaban は凍結・融解の影響を受けなかった。以上のことから，rivaroxaban が学内実習におけるCMT の凝固因子インヒビター疑似検体として使用できる可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本保健科学大学"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"24335002","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"登尾, 一平"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"山本, 隆敏","creatorNameLang":"ja"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"上妻, 行則"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-30"}],"displaytype":"detail","filename":"p131-140-kozuma.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"p131-140-kozuma","url":"https://khsu.repo.nii.ac.jp/record/214/files/p131-140-kozuma.pdf"},"version_id":"29a78afb-d665-4c4b-bc9e-1e9c5f83c4c8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cross mixing test","subitem_subject_scheme":"Other"},{"subitem_subject":"Rivaroxaban","subitem_subject_scheme":"Other"},{"subitem_subject":"DOAC","subitem_subject_scheme":"Other"},{"subitem_subject":"凝固因子インヒビター","subitem_subject_scheme":"Other"},{"subitem_subject":"学内実習","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Rivaroxaban は学内実習における交差混合試験の凝固因子インヒビターとして有用である","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Rivaroxaban は学内実習における交差混合試験の凝固因子インヒビターとして有用である"},{"subitem_title":"Rivaroxaban can be used as a coagulation inhibitor of cross mixing test during the practrium.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"12","path":["87"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-05-30"},"publish_date":"2019-05-30","publish_status":"0","recid":"214","relation_version_is_last":true,"title":["Rivaroxaban は学内実習における交差混合試験の凝固因子インヒビターとして有用である"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-04-15T07:26:36.684826+00:00"}