{"created":"2023-06-20T13:45:27.740272+00:00","id":226,"links":{},"metadata":{"_buckets":{"deposit":"cf075a84-14b9-4444-b817-37b8a553d119"},"_deposit":{"created_by":12,"id":"226","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"226"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000226","sets":["22:81:88"]},"author_link":["361","364","365","362","360","367","363","366"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"17","bibliographicPageEnd":"70","bibliographicPageStart":"59","bibliographic_titles":[{"bibliographic_title":"熊本保健科学大学研究誌"},{"bibliographic_title":"Journal of Kumamoto Health Science University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　活性化部分トロンボプラスチン時間（activated partial thromboplastin time; APTT）はプロ\nトロンビン時間（prothrombin time; PT）とともに最も一般的に行われる凝固検査である。\nAPTT の延長は，凝固因子欠乏や凝固因子インヒビター，またはループスアンチコアグラント\n（lupus anticoagulant; LA）の存在など血液凝固疾患の存在が示唆され，このような凝固時間が\n延長した際のスクリーニングとして交差混合試験（cross mixing test; CMT）がある。しかしな\nがら，これまで学内実習においては CMT の意義や技術を含め十分には教育できていなかった。\nそこで我々は， 学内実習での CMT の実施を目指し基礎的検討を行い，direct oral anticoagulant（\nDOAC）である Rivaroxaban がCMT における凝固因子インヒビター疑似検体とし\nて有用である可能性を見出した。そこで本研究では，学内実習で利用可能な Rivaroxaban の至\n適濃度および APTT 試薬を決定することを目的とした。APTT は正常血漿と Rivaroxaban を\n様々な比率で混和し，コアプレスタⓇ 2000を使用し測定した。その結果，3,200 ng/mL の\nRivaroxaban 濃度では様々な APTT 試薬存在下においてもインヒビターパターンを示したこと\nから，Rivaroxaban 3,200 ng/mL が至適濃度であり，学内実習におけるインヒビター疑似検体\nとして使用できる可能性が示唆された。なかでも，データファイ・APTT（FS）を用いた際に\nおいて，最も典型的なインヒビターパターンを示したことから，データファイ・APTT（FS）\nが学内実習の CMT において最適な APTT 試薬であることが明らかとなった。","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本保健科学大学"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12816509","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2433-5002","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"登尾, 一平"}],"nameIdentifiers":[{"nameIdentifier":"360","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山本, 隆敏"}],"nameIdentifiers":[{"nameIdentifier":"361","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"平野, 京介"}],"nameIdentifiers":[{"nameIdentifier":"362","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佛淵, 悠大"}],"nameIdentifiers":[{"nameIdentifier":"363","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡邊, 一史"}],"nameIdentifiers":[{"nameIdentifier":"364","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田邊, 香野"}],"nameIdentifiers":[{"nameIdentifier":"365","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"川口, 辰哉","creatorNameLang":"ja"}],"familyNames":[{"familyName":"川口","familyNameLang":"ja"}],"givenNames":[{"givenName":"辰哉","givenNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"366","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"上妻, 行則"}],"nameIdentifiers":[{"nameIdentifier":"367","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-05-01"}],"displaytype":"detail","filename":"p59-70-noborio.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"p59-70-noborio","url":"https://khsu.repo.nii.ac.jp/record/226/files/p59-70-noborio.pdf"},"version_id":"5972f158-bd6e-41c4-83fb-777b0f7f45ee"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cross mixing test","subitem_subject_scheme":"Other"},{"subitem_subject":"Rivaroxaba","subitem_subject_scheme":"Other"},{"subitem_subject":"DOAC","subitem_subject_scheme":"Other"},{"subitem_subject":"凝固因子インヒビター","subitem_subject_scheme":"Other"},{"subitem_subject":"学内実習","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"学内における交差混合試験理解のためのRivaroxabanの応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"学内における交差混合試験理解のためのRivaroxabanの応用"},{"subitem_title":"Application of Rivaroxaban for student's understanding of cross mixing test","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"12","path":["88"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-05-01"},"publish_date":"2020-05-01","publish_status":"0","recid":"226","relation_version_is_last":true,"title":["学内における交差混合試験理解のためのRivaroxabanの応用"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-04-15T07:26:10.470000+00:00"}