{"created":"2023-06-20T13:45:28.369226+00:00","id":237,"links":{},"metadata":{"_buckets":{"deposit":"c1943a4a-28fe-46e9-9b76-778eee02b91e"},"_deposit":{"created_by":12,"id":"237","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"237"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000237","sets":["22:81:92"]},"author_link":["403"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"18","bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"熊本保健科学大学研究誌"},{"bibliographic_title":"Journal of Kumamoto Health Science University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　Ca2+/calmodulin-dependent protein kinase II （CaMKII） はセリン・スレオニンキナーゼの一種でユビキタスに発現している。その機能は脳や心臓でよく知られている一方でそれ以外の細胞におけるCaMKII の機能や役割は発現の広さに反して明らかになっていないことが多い。本稿では免疫細胞のうち，獲得免疫に重要なリンパ球におけるCaMKII の機能をNK 細胞，T 細胞，B 細胞の順にその基本的性質と共に概説する。さらに筆者らが発見したB 細胞のIgE クラススイッチにおけるCaMKII の制御機構も紹介する。","subitem_description_type":"Abstract"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"24335002","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田邊, 香野"}],"nameIdentifiers":[{"nameIdentifier":"403","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-28"}],"displaytype":"detail","filename":"p001-010-tanabe.pdf","filesize":[{"value":"950.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"p001-010-tanabe","url":"https://khsu.repo.nii.ac.jp/record/237/files/p001-010-tanabe.pdf"},"version_id":"4ef36fac-2da8-475a-bfd3-4af453bb805a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CaMKII","subitem_subject_scheme":"Other"},{"subitem_subject":"リン酸化","subitem_subject_scheme":"Other"},{"subitem_subject":"リンパ球","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"リンパ球におけるCaMKII の機能と役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"リンパ球におけるCaMKII の機能と役割"},{"subitem_title":"The function and role of Ca2+/calmodulin-dependent protein kinase II in lymphocytes","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"12","path":["92"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-28"},"publish_date":"2021-04-28","publish_status":"0","recid":"237","relation_version_is_last":true,"title":["リンパ球におけるCaMKII の機能と役割"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-06-20T13:48:16.021964+00:00"}