{"created":"2023-06-20T13:45:29.390557+00:00","id":258,"links":{},"metadata":{"_buckets":{"deposit":"264d09fd-3953-4c0d-a850-0e83f1ab29d9"},"_deposit":{"created_by":12,"id":"258","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"258"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000258","sets":["71"]},"author_link":["50","54"],"item_10007_contributor_5":{"attribute_name":"研究分担者","attribute_value_mlt":[{"contributorAffiliations":[{"contributorAffiliationNameIdentifiers":[{"contributorAffiliationNameIdentifier":""}],"contributorAffiliationNames":[{"contributorAffiliationName":""}]}],"contributorNames":[{"contributorName":"飯山, 準一","lang":"ja"},{"contributorName":"イイヤマ, ジュンイチ","lang":"ja-Kana"}],"familyNames":[{"familyName":"飯山","familyNameLang":"ja"},{"familyName":"イイヤマ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"準一","givenNameLang":"ja"},{"givenName":"ジュンイチ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"50","nameIdentifierScheme":"WEKO"}]}]},"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2018","subitem_date_issued_type":"Issued"}]},"item_10007_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"70623510","subitem_description_type":"Other"}]},"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"熊本保健科学大学","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要：多種の悪性腫瘍に対して優れた抗腫瘍効果を示すシスプラチン（CDDP）は、一方で、副作用として容量依存性に急性腎障害を誘発する。我々は、慢性腎臓病モデルマウスに対する温和な温熱刺激の反復が、尿細管を主とした腎保護効果を示すことを報告してきた。本研究では、CDDP投与前の温和な温熱刺激（Mild systemic thermal preconditioning, MSTP）がシスプラチン腎症を軽減できるか検討した。その結果、CDDP投与によるクレアチニン値の上昇や腎組織学的に認められた尿細管上皮の脱落、嚢胞性拡大などは軽減され、CDDP投与前のMSTPは腎障害軽減に有効である可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"15K01447","subitem_description_type":"Other"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-08"}],"displaytype":"detail","filename":"kaken.nii.ac.jp_15K01447seika.pdf","filesize":[{"value":"327.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kaken.nii.ac.jp_15K01447seika","url":"https://khsu.repo.nii.ac.jp/record/258/files/kaken.nii.ac.jp_15K01447seika.pdf"},"version_id":"eb700168-2e71-41a1-8744-851a1b83b99a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"温熱プレコンディショニング","subitem_subject_scheme":"Other"},{"subitem_subject":"シスプラチン腎症","subitem_subject_scheme":"Other"},{"subitem_subject":"尿細管傷害","subitem_subject_scheme":"Other"},{"subitem_subject":"全身温熱刺激","subitem_subject_scheme":"Other"},{"subitem_subject":"シスプラチン誘発性腎症","subitem_subject_scheme":"Other"},{"subitem_subject":"腎血流","subitem_subject_scheme":"Other"},{"subitem_subject":"TRP channel","subitem_subject_scheme":"Other"},{"subitem_subject":"small HSP","subitem_subject_scheme":"Other"},{"subitem_subject":"シスプラチン誘発性腎障害","subitem_subject_scheme":"Other"},{"subitem_subject":"TRPV4","subitem_subject_scheme":"Other"},{"subitem_subject":"MYLK","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロアレイ","subitem_subject_scheme":"Other"},{"subitem_subject":"TRP channels","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"熱ショックタンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"岩下, 佳弘","creatorNameLang":"ja"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"シスプラチン腎症に対する温熱プレコンディショニングの効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"シスプラチン腎症に対する温熱プレコンディショニングの効果"},{"subitem_title":"Effects of thermal preconditioning on cisplatin nephropathy","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"12","path":["71"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-08"},"publish_date":"2022-03-08","publish_status":"0","recid":"258","relation_version_is_last":true,"title":["シスプラチン腎症に対する温熱プレコンディショニングの効果"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-04-11T08:35:48.007702+00:00"}