{"created":"2023-06-20T13:45:29.505513+00:00","id":260,"links":{},"metadata":{"_buckets":{"deposit":"eec4f0e3-f9a2-48cc-a21d-f9ec08deb5d7"},"_deposit":{"created_by":12,"id":"260","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"260"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000260","sets":["71"]},"author_link":["300"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2015","subitem_date_issued_type":"Issued"}]},"item_10007_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"70596452","subitem_description_type":"Other"}]},"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"熊本保健科学大学","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要：A型ボツリヌス毒素の鎮痛作用機序を検討した。BOTOXとA2NTXは1U/site以上で運動能力に影響した。CFA炎症ラットではBOTOX、A2NTXは痛み刺激に対して同様の鎮痛効果を示したが、炎症性の浮腫には無効であった。しかし、その鎮痛作用は抗毒素により抑制された。また、中枢作用の検討ではCFA注入群で増加したc-Fos発現がボツリヌス毒素によって抑制された。しかし、TNF-αの発現では影響与えなかった。A型ボツリヌス毒素注入群でAd、C線維の伝導速度が有意にCFA群より遅かった。これらの結果から、A型ボツリヌス毒素は中枢神経に作用し、抗炎症作用はなく抗侵害作用のみを持つことが示された。","subitem_description_type":"Abstract"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"26860390","subitem_description_type":"Other"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-08"}],"displaytype":"detail","filename":"kaken.nii.ac.jp_26860390seika.pdf","filesize":[{"value":"938.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kaken.nii.ac.jp_26860390seika","url":"https://khsu.repo.nii.ac.jp/record/260/files/kaken.nii.ac.jp_26860390seika.pdf"},"version_id":"a887ba03-55e4-4c7a-b86f-2d66161d9ce8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ボツリヌス毒素","subitem_subject_scheme":"Other"},{"subitem_subject":"A2NTX","subitem_subject_scheme":"Other"},{"subitem_subject":"BOTOX","subitem_subject_scheme":"Other"},{"subitem_subject":"鎮痛効果","subitem_subject_scheme":"Other"},{"subitem_subject":"急性疼痛","subitem_subject_scheme":"Other"},{"subitem_subject":"慢性疼痛","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"申, 敏哲","creatorNameLang":"ja"},{"creatorName":"Shin , MinChul","creatorNameLang":"en"}],"familyNames":[{},{}],"givenNames":[{},{}],"nameIdentifiers":[{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Invivo及びInvitro記録法を用いたボツリヌス毒素の鎮痛作用機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Invivo及びInvitro記録法を用いたボツリヌス毒素の鎮痛作用機序の解明"},{"subitem_title":"Antinociceptive effects of BOTOX and A2NTX on CFA-induced hyperalgesia in rat","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"12","path":["71"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-08"},"publish_date":"2022-03-08","publish_status":"0","recid":"260","relation_version_is_last":true,"title":["Invivo及びInvitro記録法を用いたボツリヌス毒素の鎮痛作用機序の解明"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-04-11T08:10:43.184800+00:00"}