{"created":"2023-06-20T13:45:29.767575+00:00","id":265,"links":{},"metadata":{"_buckets":{"deposit":"bdfedb2d-6499-4399-9c41-bdf60f29fc03"},"_deposit":{"created_by":12,"id":"265","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"265"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000265","sets":["71"]},"author_link":["407"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017","subitem_date_issued_type":"Issued"}]},"item_10007_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"60315299","subitem_description_type":"Other"}]},"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"熊本保健科学大学","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要：ミトコンドリア内に不良タンパク質が蓄積した場合、ミトコンドリアストレス伝達経路が活性化され、その情報がミトコンドリアから核へと伝えられる。すると、ミトコンドリアのunfolded protein response（UPR）が活性化され、分子シャペロンやプロテアーゼ類の発現が誘導される。本研究では、哺乳類におけるミトコンドリアストレス伝達経路を解明するため、その候補因子であるABCB10等の機能解析を試みた。その結果、ABCB10の発現量を低下させると、ミトコンドリアのUPRが低下することがわかった。このことから、ABCB10はミトコンドリアストレス伝達経路に関与することが示唆された。","subitem_description_type":"Abstract"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"26460378","subitem_description_type":"Other"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-08"}],"displaytype":"detail","filename":"kaken.nii.ac.jp_26460378seika.pdf","filesize":[{"value":"82.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kaken.nii.ac.jp_26460378seika","url":"https://khsu.repo.nii.ac.jp/record/265/files/kaken.nii.ac.jp_26460378seika.pdf"},"version_id":"1ddc6d27-1fce-41f8-8a6a-017eb5bbf306"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ミトコンドリア","subitem_subject_scheme":"Other"},{"subitem_subject":"ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"ABCB10","subitem_subject_scheme":"Other"},{"subitem_subject":"TMEM65","subitem_subject_scheme":"Other"},{"subitem_subject":"ストレス応答","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスポーター","subitem_subject_scheme":"Other"},{"subitem_subject":"膜タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"矢野, 正人"}],"nameIdentifiers":[{"nameIdentifier":"407","nameIdentifierScheme":"WEKO"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"哺乳類のミトコンドリアストレス伝達経路の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"哺乳類のミトコンドリアストレス伝達経路の解明"},{"subitem_title":"Analysis of mitochondrial stress signaling pathway","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"12","path":["71"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-08"},"publish_date":"2022-03-08","publish_status":"0","recid":"265","relation_version_is_last":true,"title":["哺乳類のミトコンドリアストレス伝達経路の解明"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-06-20T13:48:44.437089+00:00"}