{"created":"2023-06-20T13:45:29.906323+00:00","id":268,"links":{},"metadata":{"_buckets":{"deposit":"c9745c73-980b-4348-8ecc-eefdf1df603f"},"_deposit":{"created_by":12,"id":"268","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"268"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000268","sets":["71"]},"author_link":["295","438"],"item_10007_contributor_5":{"attribute_name":"研究分担者","attribute_value_mlt":[{"contributorNames":[{"contributorName":"吉村, 恵"}],"nameIdentifiers":[{"nameIdentifier":"438","nameIdentifierScheme":"WEKO"}]}]},"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2017","subitem_date_issued_type":"Issued"}]},"item_10007_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"60619675","subitem_description_type":"Other"}]},"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"熊本保健科学大学","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要：ギプス固定した右後肢に対する振動刺激はギプス抜去後の他動的な右足関節背屈可動性、右膝関節の動的機能、歩行能力を改善した。正常マウスの右後肢で痛覚閾値を測定し、左後肢に振動刺激を加えると痛覚閾値の上昇が見られた。生体動物の脊髄後角から単一神経細胞を記録した条件で右後肢にピンポイント痛覚刺激を行うと、抑制性シナプス電流の増加部位は興奮性のそれよりも大きく、その範囲はより近位方向に拡がっていた。また、下降性抑制系の一つであるノルアドレナリンは、痛覚刺激による興奮性シナプス電流の増加を有意に抑制した。これらのことは、特に感覚系の定量的改善効果を脊髄後角レベルで確かめるための基盤になると考えられた。","subitem_description_type":"Abstract"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"26350646","subitem_description_type":"Other"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-08"}],"displaytype":"detail","filename":"kaken.nii.ac.jp_26350646seika.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kaken.nii.ac.jp_26350646seika","url":"https://khsu.repo.nii.ac.jp/record/268/files/kaken.nii.ac.jp_26350646seika.pdf"},"version_id":"f5dc727c-3145-4626-bec3-91bf9e78f59d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"運動評価","subitem_subject_scheme":"Other"},{"subitem_subject":"感覚閾値評価","subitem_subject_scheme":"Other"},{"subitem_subject":"行動評価","subitem_subject_scheme":"Other"},{"subitem_subject":"キャスト固定モデル動物","subitem_subject_scheme":"Other"},{"subitem_subject":"治療効果","subitem_subject_scheme":"Other"},{"subitem_subject":"in vivo パッチクランプ法","subitem_subject_scheme":"Other"},{"subitem_subject":"脊髄後角","subitem_subject_scheme":"Other"},{"subitem_subject":"キャストモデル","subitem_subject_scheme":"Other"},{"subitem_subject":"感覚閾値","subitem_subject_scheme":"Other"},{"subitem_subject":"振動刺激","subitem_subject_scheme":"Other"},{"subitem_subject":"生体マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"生体パッチクランプ法","subitem_subject_scheme":"Other"},{"subitem_subject":"興奮性シナプス後電流","subitem_subject_scheme":"Other"},{"subitem_subject":"下降性抑制系","subitem_subject_scheme":"Other"},{"subitem_subject":"ピンチ刺激","subitem_subject_scheme":"Other"},{"subitem_subject":"キャスト固定マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"運動機能","subitem_subject_scheme":"Other"},{"subitem_subject":"感覚機能","subitem_subject_scheme":"Other"},{"subitem_subject":"膝関節の可動性","subitem_subject_scheme":"Other"},{"subitem_subject":"足関節の可動性","subitem_subject_scheme":"Other"},{"subitem_subject":"ギプス固定マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"脊髄後角部","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"土井, 篤"}],"nameIdentifiers":[{"nameIdentifier":"295","nameIdentifierScheme":"WEKO"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"リハ治療効果を脊髄で評価する基盤研究： In vivoパッチクランプ法を用いて","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"リハ治療効果を脊髄で評価する基盤研究： In vivoパッチクランプ法を用いて"},{"subitem_title":"Scientific research for evaluation of the impact of rehabilitative training in the spinal cord","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"12","path":["71"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-08"},"publish_date":"2022-03-08","publish_status":"0","recid":"268","relation_version_is_last":true,"title":["リハ治療効果を脊髄で評価する基盤研究： In vivoパッチクランプ法を用いて"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-06-20T13:48:40.546326+00:00"}