{"created":"2023-06-20T13:45:30.095094+00:00","id":272,"links":{},"metadata":{"_buckets":{"deposit":"174c72a3-d609-4ce6-bff8-32b72df0b50e"},"_deposit":{"created_by":12,"id":"272","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"272"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000272","sets":["71"]},"author_link":["440"],"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2014","subitem_date_issued_type":"Issued"}]},"item_10007_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"70389542","subitem_description_type":"Other"}]},"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"熊本保健科学大学","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要：HIVプロテアーゼ（PR）の二量体形成阻止（PDI）活性を有するプロテアーゼ阻害剤Tipranavir（TPV）に対する耐性HIVより同定したL24MとL33IはPDI活性を喪失させることを確認、またそのようなアミノ酸置換はPR の folding に重要とされる部位とオーバーラップする 3 領域に集簇した。一方、ESI-MS によるPR前駆体モデルタンパク質とTPVとの結合解析より、TPVはその単量体と二量体に結合することを確認した。更に PDI活性を喪失させる領域と同じアミノ酸配列を持つトリペプチドの一部はPDI活性 を有しており今後の薬剤開発のデザイン等に資するものと思われる。","subitem_description_type":"Abstract"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"24791031","subitem_description_type":"Other"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-08"}],"displaytype":"detail","filename":"kaken.nii.ac.jp_24791031seika.pdf","filesize":[{"value":"297.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kaken.nii.ac.jp_24791031seika","url":"https://khsu.repo.nii.ac.jp/record/272/files/kaken.nii.ac.jp_24791031seika.pdf"},"version_id":"01046ae3-2246-4767-8457-0a6a2ad77657"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HIV","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテアーゼ阻害剤","subitem_subject_scheme":"Other"},{"subitem_subject":"薬剤耐性","subitem_subject_scheme":"Other"},{"subitem_subject":"HIV-1","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"青木, 学"}],"nameIdentifiers":[{}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"低分子化合物によるＨＩＶプロテアーゼ二量体形成阻害機構の解明と創薬への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"低分子化合物によるＨＩＶプロテアーゼ二量体形成阻害機構の解明と創薬への応用"},{"subitem_title":"Elucidation of TPV's protease dimerization inhibition (PDI) mechanism and development of potent compounds possessing PDI activity","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"12","path":["71"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-08"},"publish_date":"2022-03-08","publish_status":"0","recid":"272","relation_version_is_last":true,"title":["低分子化合物によるＨＩＶプロテアーゼ二量体形成阻害機構の解明と創薬への応用"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-06-20T13:48:35.044012+00:00"}