{"created":"2023-06-20T13:45:30.532254+00:00","id":281,"links":{},"metadata":{"_buckets":{"deposit":"740811c5-f972-4b97-89cd-f044ca88b43f"},"_deposit":{"created_by":12,"id":"281","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"281"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000281","sets":["71"]},"author_link":["452","451","450"],"item_10007_contributor_5":{"attribute_name":"研究分担者","attribute_value_mlt":[{"contributorNames":[{"contributorName":"大池, 正宏"}],"nameIdentifiers":[{"nameIdentifier":"451","nameIdentifierScheme":"WEKO"}]},{"contributorNames":[{"contributorName":"木村, 千稚 "}],"nameIdentifiers":[{"nameIdentifier":"452","nameIdentifierScheme":"WEKO"}]}]},"item_10007_date_8":{"attribute_name":"報告年度","attribute_value_mlt":[{"subitem_date_issued_datetime":"2008","subitem_date_issued_type":"Issued"}]},"item_10007_description_10":{"attribute_name":"研究代表者番号","attribute_value_mlt":[{"subitem_description":"80037506","subitem_description_type":"Other"}]},"item_10007_description_11":{"attribute_name":"研究機関","attribute_value_mlt":[{"subitem_description":"熊本保健科学大学","subitem_description_type":"Other"}]},"item_10007_description_13":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究概要：研究成果の概要:Th2 サイトカインであるIL-4 及びIL-13 は気道平滑筋の収縮増強効果を有し、この増強効果には細胞内Ca 濃度や収縮蛋白のCa 感受性、MLCK のリン酸化は全く関与しないことを明らかにした。結論としてTh2 サイトカインによる収縮増強効果にはMMP-1 が関与し気道平滑筋細胞と細胞外コラーゲンの網状組織の再構築が関与することを世界に先駆け明らかにした。","subitem_description_type":"Abstract"}]},"item_10007_description_9":{"attribute_name":"研究課題番号","attribute_value_mlt":[{"subitem_description":"19390065","subitem_description_type":"Other"}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-08"}],"displaytype":"detail","filename":"kaken.nii.ac.jp_19390065seika.pdf","filesize":[{"value":"20.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"kaken.nii.ac.jp_19390065seika","url":"https://khsu.repo.nii.ac.jp/record/281/files/kaken.nii.ac.jp_19390065seika.pdf"},"version_id":"cafd8d9e-6ba3-4c19-8ddb-ddcb628f4d18"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"気道","subitem_subject_scheme":"Other"},{"subitem_subject":"平滑筋","subitem_subject_scheme":"Other"},{"subitem_subject":"気道過敏性","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-13","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-4","subitem_subject_scheme":"Other"},{"subitem_subject":"Ca^<2+>","subitem_subject_scheme":"Other"},{"subitem_subject":"ミオシン軽鎖","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_researcher":{"attribute_name":"研究代表者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊東, 祐之"}],"nameIdentifiers":[{"nameIdentifier":"450","nameIdentifierScheme":"WEKO"}]}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Th2サイトカインによる全く新しい気道過敏性発生機序の分子薬理学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Th2サイトカインによる全く新しい気道過敏性発生機序の分子薬理学的研究"},{"subitem_title":"Dual Modulation of Airway Smooth Muscle Contraction by Th2 Cytokines via Matrix Metalloproteinase-1 Production","subitem_title_language":"en"}]},"item_type_id":"10007","owner":"12","path":["71"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-08"},"publish_date":"2022-03-08","publish_status":"0","recid":"281","relation_version_is_last":true,"title":["Th2サイトカインによる全く新しい気道過敏性発生機序の分子薬理学的研究"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-06-20T13:48:19.301139+00:00"}