{"created":"2023-06-20T13:45:30.748359+00:00","id":286,"links":{},"metadata":{"_buckets":{"deposit":"a32020b8-1743-4fa5-9ceb-455dbf6b3cdf"},"_deposit":{"created_by":12,"id":"286","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"286"},"status":"published"},"_oai":{"id":"oai:khsu.repo.nii.ac.jp:00000286","sets":["22:81:93"]},"author_link":["122"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"19","bibliographicPageEnd":"38","bibliographicPageStart":"31","bibliographic_titles":[{"bibliographic_title":"熊本保健科学大学研究誌"},{"bibliographic_title":"Journal of Kumamoto Health Science University","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1．ラット脳黒質ドーパミン（DA）ニューロンのシナプス・ブートン標本を用いてグルタミン酸（Glu）作動性神経終末部から自発的に放出されるGlu 惹起の興奮性シナプス後電流（sEPSC）を記録した。sEPSC の発生頻度，電流振幅および電流キネティクスを指標に，DAニューロンへのニコチンの直接，間接的作用を検討した。\n2．ニコチンはDA ニューロンに入力するGlu 作動性神経終末部から放出されるGlu によって惹起されるsEPSC の発生頻度と電流振幅の増加やDA ニューロン細胞体に興奮性内向き電流を発生した。したがってACh 作動性ニコチン様受容体（nAChR）の分布は先行研究で明らかとなったDA 神経終末部のみならずGlu 作動性神経終末部とDA ニューロン細胞体上にも存在することが今回明らかとなった。\n3．ニコチンはsEPSC の活性，不活性の電流キネティクスを変化させず，またシナプス内Glu受容体にも作用しなかった。よってニコチン存在下のsEPSC 電流振幅の増加はGlu 作動性神経終末からのGlu 放出量の増加に依存する。","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本保健科学大学"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"24335002","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":""}],"affiliationNames":[{"affiliationName":""}]}],"creatorNames":[{"creatorName":"野中, 喜久","creatorNameLang":"ja"}],"familyNames":[{}],"givenNames":[{}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-29"}],"displaytype":"detail","filename":"p031-038-nonaka.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"p031-038-nonaka","url":"https://khsu.repo.nii.ac.jp/record/286/files/p031-038-nonaka.pdf"},"version_id":"e9d95916-e527-4db2-8d48-76a402263e01"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DA ニューロン","subitem_subject_scheme":"Other"},{"subitem_subject":"Glu 作動性神経終末部","subitem_subject_scheme":"Other"},{"subitem_subject":"自発性の興奮性シナプス後電流（sEPSC）","subitem_subject_scheme":"Other"},{"subitem_subject":"ACh 作動性ニコチン様受容体（nAChRs）の存在部位","subitem_subject_scheme":"Other"},{"subitem_subject":"シナプス・ブートン標本","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ドーパミン神経細胞に入力するグルタミン酸作動性神経終末部上 のコリン作動性ニコチン様受容体（nAChR）の機能的役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ドーパミン神経細胞に入力するグルタミン酸作動性神経終末部上 のコリン作動性ニコチン様受容体（nAChR）の機能的役割"},{"subitem_title":"Functional role of nicotinic Ach receptors（ nAChRs） on presynaptic glutamatergic nerve endings projecting to dopamine neuron.","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"12","path":["93"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-02"},"publish_date":"2022-04-02","publish_status":"0","recid":"286","relation_version_is_last":true,"title":["ドーパミン神経細胞に入力するグルタミン酸作動性神経終末部上 のコリン作動性ニコチン様受容体（nAChR）の機能的役割"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-04-18T02:03:48.058612+00:00"}