{"_buckets": {"deposit": "c2761f65-7210-4998-946c-ec5fd81a294e"}, "_deposit": {"created_by": 12, "id": "146", "owners": [12], "pid": {"revision_id": 0, "type": "depid", "value": "146"}, "status": "published"}, "_oai": {"id": "oai:khsu.repo.nii.ac.jp:00000146", "sets": ["71"]}, "author_link": ["38"], "item_10007_date_8": {"attribute_name": "報告年度", "attribute_value_mlt": [{"subitem_date_issued_datetime": "2013", "subitem_date_issued_type": "Issued"}]}, "item_10007_description_10": {"attribute_name": "研究代表者番号", "attribute_value_mlt": [{"subitem_description": "80389543", "subitem_description_type": "Other"}]}, "item_10007_description_13": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "研究概要：Pr55Gagはホスファチジルイノシトール4,5-2リン酸｛PI(4,5)P2｝を介して宿主の細胞膜に結合することによりHIV-1ウイルス粒子を形成する。研究代表者らは、PI(4,5)P2よりも高度にリン酸化された人工PI(2,3,4,5,6) 5リン酸アナログを種々合成し、それらとPr55Gagの細胞膜結合部位であるMA蛋白質との結合活性を評価した。その結果、MA蛋白質に対して、同等の炭素鎖をもつPI(4,5)P2よりも約70倍強く結合するDi-C7-PI(2,3,4,5,6)P5 (化合物2)を見出した。本研究はPr55Gagの膜移行を阻害する化合物創製の基礎になりうると考えられる。", "subitem_description_type": "Abstract"}]}, "item_10007_description_9": {"attribute_name": "研究課題番号", "attribute_value_mlt": [{"subitem_description": "24790124", "subitem_description_type": "Other"}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2022-03-07"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "kaken.nii.ac.jp_24790124seika.pdf", "filesize": [{"value": "343.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 343700.0, "url": {"label": "kaken.nii.ac.jp_19592620seika", "url": "https://khsu.repo.nii.ac.jp/record/146/files/kaken.nii.ac.jp_24790124seika.pdf"}, "version_id": "5a4d8f25-3f86-4c95-b545-4b62dd5c6404"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "抗エイズ薬", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Pr55Gag", "subitem_subject_scheme": "Other"}, {"subitem_subject": "PI(4,5)P2", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HIV-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "リン脂質", "subitem_subject_scheme": "Other"}, {"subitem_subject": "ジアシルグリセロール", "subitem_subject_scheme": "Other"}, {"subitem_subject": "イノシトールリン酸", "subitem_subject_scheme": "Other"}, {"subitem_subject": "BIACORE", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_researcher": {"attribute_name": "研究代表者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "安楽, 健作"}], "nameIdentifiers": [{"nameIdentifier": "38", "nameIdentifierScheme": "WEKO"}]}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "Ｐｒ５５Ｇａｇの膜移行を阻害する抗エイズ薬", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Ｐｒ５５Ｇａｇの膜移行を阻害する抗エイズ薬"}, {"subitem_title": "Design and synthesis of anti-HIV agents that inhibit the Pr55Gag membrane localization", "subitem_title_language": "en"}]}, "item_type_id": "10007", "owner": "12", "path": ["71"], "permalink_uri": "https://khsu.repo.nii.ac.jp/records/146", "pubdate": {"attribute_name": "公開日", "attribute_value": "2015-07-27"}, "publish_date": "2015-07-27", "publish_status": "0", "recid": "146", "relation": {}, "relation_version_is_last": true, "title": ["Ｐｒ５５Ｇａｇの膜移行を阻害する抗エイズ薬"], "weko_shared_id": -1}